5-HT5 Receptors

Overview

Two genes have been identified that give rise to 5-ht5a and 5-ht5b proteins with structures consistent with GPCRs although in humans the 5-ht5b gene is a pseudogene since a stop... [read more] codon has evolved that would, if expressed, result in a truncated protein devoid of key functional moieties of the receptor. The predicted protein sequences display less than 38% amino acid sequence identity to other 5-HT GPCRs, thus clearly distinguishing the 5-ht5a protein from other 5-HT receptors.5-ht5a is yet to receive receptor status since no robust response signal in native tissue has been described. Native 5-ht5a protein would appear G-protein coupled and recombinant expression allows coupling via various transduction systems including the G-protein mediated inhibition of adenylate cyclase. A selective antagonist based on recombinant protein function has been identified (SB699551-A). [close]