5-HT7 receptor - Tanso Biosciences

Overview

The 5-HT7 receptor is a GPCR that couples via Gs to increase cAMP production with some other transduction pathways also implicated in receptor function (e.g. ERK, Galpha12/RhoA/Cdc42). The structure displays... [read more] less than 39% amino acid sequence identity to other 5-HT receptors. Several splice variants have been described.PharmacologyVarious selective 5-HT7 receptor agonists (e.g. LP-12, AS-19 [partial agonist]) and antagonists (e.g. SB 269970, SB656104-A) have been described.Clinical significanceSimilar to the 5-HT6 receptor, various non-selective psychotropic drugs also display high affinity for the 5-HT7 receptor (e.g. asenapine, clozapine, pimozide), although the consequences of this interaction are also not clear. [close]


Human	HTR7 5-hydroxytryptamine receptor 7
Mouse	Htr7 5-hydroxytryptamine (serotonin) receptor 7

Human

HTR7

5-hydroxytryptamine receptor 7

Mouse

Htr7

5-hydroxytryptamine (serotonin) receptor 7

Receptor	Family	Assays
HTR7	5-Hydroxytryptamine receptors ⋅ 5-HT7 receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Safety Premium ⋅ Psychiatry ⋅ Neurology ⋅ Musculoskeletal ⋅ à la carte
Htr7	5-Hydroxytryptamine receptors ⋅ 5-HT7 receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte

To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.

Functional Always active

The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.

Preferences

The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.

Statistics

The technical storage or access that is used exclusively for statistical purposes. The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.

Marketing

The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.