Endothelin receptors

Overview

Endothelin receptors are activated by the endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3).
Excerpt from IUPHAR/BPS Guide to Pharmacology
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Species
Receptor
Family
Assays
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Safety
Safety Premium
Immunology/Infection
Oncology
Hematology
Endocrinology/Metabolism
Psychiatry
Neurology
Ophthalmology
Cardiology
Respiratory
Gastrointestinal
Dermatology
Musculoskeletal
Urology/Reproduction
à la carte
Reference agonist:
ET‐1
EC50:
5.5 nM
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Safety Premium
Immunology/Infection
Oncology
Hematology
Endocrinology/Metabolism
Neurology
Ophthalmology
Cardiology
Respiratory
Gastrointestinal
Dermatology
Musculoskeletal
Urology/Reproduction
à la carte
Reference agonist:
ET‐1
EC50:
5.0 nM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
ET‐1
EC50:
10 nM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
ET‐1
EC50:
10 nM