Glycoprotein hormone receptors

Overview

Glycoprotein hormone receptors are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique... [read more] β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [1,2].

References

Sairam MR. Role of carbohydrates in glycoprotein hormone signal transduction. FASEB J 1989;3:1915-26.
Davidson JS, Assefa D, Pawson A, et al. Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment. Biochemistry 1997;36:12881-9.

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Human	FSHR follicle stimulating hormone receptor
Human	LHCGR luteinizing hormone/choriogonadotropin receptor
Human	TSHR thyroid stimulating hormone receptor
Mouse	Fshr follicle stimulating hormone receptor
Mouse	Lhcgr luteinizing hormone/choriogonadotropin receptor

Human

FSHR

follicle stimulating hormone receptor

Human

LHCGR

luteinizing hormone/choriogonadotropin receptor

Human

TSHR

thyroid stimulating hormone receptor

Mouse

Fshr

follicle stimulating hormone receptor

Mouse

Lhcgr

luteinizing hormone/choriogonadotropin receptor

Species	Receptor	Family	Assays
Human	FSHR follicle stimulating hormone receptor	Glycoprotein hormone receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Endocrinology/Metabolism ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: FSH EC50: 8.6 ng/ml
Human	LHCGR luteinizing hormone/choriogonadotropin receptor	Glycoprotein hormone receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Endocrinology/Metabolism ⋅ Dermatology ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: rLHα/β EC50: 26 ng/ml
Human	TSHR thyroid stimulating hormone receptor	Glycoprotein hormone receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Endocrinology/Metabolism ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: TSH EC50: 18 ng/ml
Mouse	Fshr follicle stimulating hormone receptor	Glycoprotein hormone receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: FSH EC50: 10 ng/mL
Mouse	Lhcgr luteinizing hormone/choriogonadotropin receptor	Glycoprotein hormone receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: rLHα/β EC50: 7.7 ng/mL

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