Melatonin receptors

Overview

Melatonin receptors are activated by the endogenous ligands melatonin and clinically used drugs like ramelteon, agomelatine and tasimelteon.
Excerpt from IUPHAR/BPS Guide to Pharmacology
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Species
Receptor
Family
Assays
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Ophthalmology
à la carte
Reference agonist:
melatonin
EC50:
100 pM
Human
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Human non-orphan GPCRs
Endocrinology/Metabolism
Urology/Reproduction
à la carte
Reference agonist:
melatonin
EC50:
95 pM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
melatonin
EC50:
110 pM
Mouse
Available
Assay modes:
Agonist
Inverse agonist
Antagonist
PAM
NAM
Panels:
Mouse non-orphan GPCRs
à la carte
Reference agonist:
melatonin
EC50:
230 pM