Platelet-activating factor receptor

Overview

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is an ether phospholipid mediator associated with platelet coagulation, but also subserves inflammatory roles. The PAF receptor is activated by PAF and other suggested endogenous ligands... [read more] are oxidized phosphatidylcholine [1] and lysophosphatidylcholine [2]. It may also be activated by bacterial lipopolysaccharide [3].

References

Marathe GK, Davies SS, Harrison KA, et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem 1999;274:28395-404.
Ogita T, Tanaka Y, Nakaoka T, et al. Lysophosphatidylcholine transduces Ca2+ signaling via the platelet-activating factor receptor in macrophages. Am J Physiol 1997;272:H17-24.
Nakamura M, Honda Z, Waga I, et al. Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor. FEBS Lett 1992;314:125-9.

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Human	PTAFR platelet activating factor receptor
Mouse	Ptafr platelet-activating factor receptor

Human

PTAFR

platelet activating factor receptor

Mouse

Ptafr

platelet-activating factor receptor

Species	Receptor	Family	Assays
Human	PTAFR platelet activating factor receptor	Platelet-activating factor receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Hematology ⋅ Ophthalmology ⋅ Cardiology ⋅ Respiratory ⋅ Gastrointestinal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: CH3‐carbamyl PAF C‐16 EC50: 840 pM
Mouse	Ptafr platelet-activating factor receptor	Platelet-activating factor receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: CH3‐carbamyl PAF C‐16 EC50: 480 pM

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