QRFP receptor - Tanso Biosciences

Overview

The human gene encoding the QRFP receptor (QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by Lee et al.... [read more] from a hypothalamus cDNA library [1]. However, the reported cDNA (AF411117) is a chimera with bases 1-127 derived from chromosome 1 and bases 155-1368 derived from chromosome 4. When corrected, QRFPR (also referred to as SP9155 or AQ27) encodes a 431 amino acid protein that shares sequence similarities in the transmembrane spanning regions with other peptide receptors. These include neuropeptide FF2 (38%), neuropeptide Y₂ (37%) and galanin Gal₁ (35%) receptors.

Reference

Lee DK, Nguyen T, Lynch KR, et al. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 2001;275:83-91.

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Human	QRFPR pyroglutamylated RFamide peptide receptor
Mouse	Qrfpr pyroglutamylated RFamide peptide receptor

Human

QRFPR

pyroglutamylated RFamide peptide receptor

Mouse

Qrfpr

pyroglutamylated RFamide peptide receptor

Species	Receptor	Family	Assays
Human	QRFPR pyroglutamylated RFamide peptide receptor	QRFP receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ à la carte	Reference agonist: QRFP EC50: 720 pM
Mouse	Qrfpr pyroglutamylated RFamide peptide receptor	QRFP receptor	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: QRFP EC50: 5.2 nM

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