Human OPRK1

Figure. Concentration-dependent activation of OPRK1 by dynorphin A

Reporter cells were transfected with either the expression plasmid for human opioid receptor kappa 1 (OPRK1) or the mock plasmid and treated with various concentrations of dynorphin A. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 8.2 nM.