Human HCRTR1

Figure. Concentration-dependent activation of HCRTR1 by orexin A

Reporter cells were transfected with either the expression plasmid for human hypocretin receptor 1 (HCRTR1) or the mock plasmid and treated with various concentrations of orexin A. Data points shown are the mean ± SEM of an experiment (n = 3), and the curve is a fit to Hill equation with an EC50 of 1.6 nM.