Somatostatin receptors - Tanso Biosciences

Overview

Somatostatin (somatotropin release inhibiting factor) is an abundant neuropeptide, which acts on five subtypes of somatostatin receptor (SST₁-SST₅; nomenclature as agreed by the NC-IUPHAR Subcommittee on Somatostatin Receptors [1]). Activation... [read more] of these receptors produces a wide range of physiological effects throughout the body including the inhibition of secretion of many hormones. Endogenous ligands for these receptors are somatostatin-14 (SRIF-14) and somatostatin-28 (SRIF-28). cortistatin-14 has also been suggested to be an endogenous ligand for somatostatin receptors [2].

References

Günther T, Tulipano G, Dournaud P, et al. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev 2018;70:763-835.
de Lecea L, Criado JR, Prospero-Garcia O, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 1996;381:242-5.

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Human	SSTR1 somatostatin receptor 1
Human	SSTR2 somatostatin receptor 2
Human	SSTR3 somatostatin receptor 3
Human	SSTR4 somatostatin receptor 4
Human	SSTR5 somatostatin receptor 5
Mouse	Sstr1 somatostatin receptor 1
Mouse	Sstr2 somatostatin receptor 2
Mouse	Sstr3 somatostatin receptor 3
Mouse	Sstr4 somatostatin receptor 4
Mouse	Sstr5 somatostatin receptor 5

Human

SSTR1

somatostatin receptor 1

Human

SSTR2

somatostatin receptor 2

Human

SSTR3

somatostatin receptor 3

Human

SSTR4

somatostatin receptor 4

Human

SSTR5

somatostatin receptor 5

Mouse

Sstr1

somatostatin receptor 1

Mouse

Sstr2

somatostatin receptor 2

Mouse

Sstr3

somatostatin receptor 3

Mouse

Sstr4

somatostatin receptor 4

Mouse

Sstr5

somatostatin receptor 5

Species	Receptor	Family	Assays
Human	SSTR1 somatostatin receptor 1	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 23 nM
Human	SSTR2 somatostatin receptor 2	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Oncology ⋅ Endocrinology/Metabolism ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 3.1 nM
Human	SSTR3 somatostatin receptor 3	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ Gastrointestinal ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 3.2 nM
Human	SSTR4 somatostatin receptor 4	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Immunology/Infection ⋅ Oncology ⋅ Hematology ⋅ Neurology ⋅ Ophthalmology ⋅ Respiratory ⋅ Dermatology ⋅ Musculoskeletal ⋅ Urology/Reproduction ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 290 pM
Human	SSTR5 somatostatin receptor 5	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Human non-orphan GPCRs ⋅ Neurology ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 1.7 nM
Mouse	Sstr1 somatostatin receptor 1	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 8.0 nM
Mouse	Sstr2 somatostatin receptor 2	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 7.0 nM
Mouse	Sstr3 somatostatin receptor 3	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 8.1 nM
Mouse	Sstr4 somatostatin receptor 4	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 1.3 nM
Mouse	Sstr5 somatostatin receptor 5	Somatostatin receptors	Available Assay modes: Agonist ⋅ Inverse agonist ⋅ Antagonist ⋅ PAM ⋅ NAM Panels: Mouse non-orphan GPCRs ⋅ à la carte	Reference agonist: somatostatin‐14 EC50: 13 nM

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